Please enter your Email address to subscribein mail list.
Notice: Undefined variable: msg in D:\HostingSpaces\elmadaen\sabaapharmagroup.com\wwwroot\inc\left_nav.php on line 62
Notice: Undefined index: hid in D:\HostingSpaces\elmadaen\sabaapharmagroup.com\wwwroot\product_details.php on line 13
Mechanism of Action:
The precise mechanisms by which topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV.