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Topiramate

DESCRIPTION Topiramate is a sulfamate-substituted monosaccharide. TOPIRAMATE (topiramate) Tablets are available as 25 mg, 100 mg, round tablets for oral administration. Mechanism of Action: The precise mechanisms by which topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV. CONTRAINDICATIONS TOPIRAMATE is contraindicated in patients with a history of hypersensitivity to any component of this product. Withdrawal of AEDs Antiepileptic drugs, including TOPIRAMATE, should be withdrawn gradually to minimize the potential of increased seizure frequency. Drug Interactions: In vitro studies indicate that topiramate does not inhibit enzyme activity for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4/5 isozymes. DOSAGE AND ADMINISTRATION Epilepsy Migraine
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DESCRIPTION Topiramate is a sulfamate-substituted monosaccharide. TOPIRAMATE (topiramate) Tablets are available as 25 mg, 100 mg, round tablets for oral administration. Mechanism of Action: The precise mechanisms by which topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV. CONTRAINDICATIONS TOPIRAMATE is contraindicated in patients with a history of hypersensitivity to any component of this product. Withdrawal of AEDs Antiepileptic drugs, including TOPIRAMATE, should be withdrawn gradually to minimize the potential of increased seizure frequency. Drug Interactions: In vitro studies indicate that topiramate does not inhibit enzyme activity for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4/5 isozymes. DOSAGE AND ADMINISTRATION Epilepsy Migraine
 
 
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